Systems engineering to systems biology

1 Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 2 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 3 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA and 4 Department of Genetics, Harvard Medical School, Boston, MA, USA * Corresponding author. Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 2115, USA. Tel.: þ 1 617 632 5180; Fax: þ 1 617 632 5739; E-mail: [email protected]